Eurofins Evic Romania, part of Eurofins Cosmetics & Personal business line, has established a research partnership with Bayer, to assess the performance in healthy adults with dry skin of three new dexpanthenol-containing emollients containing increasing lipid. This work has been the subject of a publication in the prestigious scientific journal Cosmetics

by Hans Stettler ¹,* Hans  , Raffaella de Salvo ¹, Rozalia Olsavszky ², Elena Alina Nanu ², Veronica Dumitru ² and Sonja Trapp¹

1)Bayer Consumer Care AG, Peter Merian-Strasse 84, CH-4002 Basel, Switzerland

2) Eurofins Evic Product Testing Romania SRL, 64-66, Marasesti Avenue, RO-040256 Bucharest, Romania

Abstract

Three studies were conducted with three new dexpanthenol-containing emollients contain-ing increasing lipid contents (Emollients 1–3) to assess their performances in healthy adults with dryskin.

All three studies (N = 42 each) followed virtually the same design. A single skin application of the study product was performed followed by once-daily usage.

• Skin hydration,
• transepidermal water loss (TEWL),
• skin biomechanical properties,
• and lipid content of the stratum corneum (SC)

were regularly assessed over the 28-day study period; a subset (N = 22) underwent a sodium laurylsulfate (SLS) challenge prior to product application.

All three emollients were well tolerated and showed good performances with only minor differences in instrumental measurements. After single and prolonged once-daily applications of Emollients 1–3 to dry skin and dry SLS-damaged skin, skin hydration significantly increased from baseline (BL) (by 38.1–72.4% in unchallenged skin,p< 0.001for all three).

This was paralleled by significant increases in skin elasticity parameters.

Usage of Emollients 1 and 3 caused increases from BL in SC cholesterol (by 9.8–12.5%,p< 0.05 for both) and SC free fatty acid levels (by 3.7–26.3%,p< 0.05 for both) at the end of the study.

No sustained effects on TEWL were recorded. Our findings support the once-daily use of all three emollients in adults with dry skin.