By by ELIZABETH BRUNING, BSc Hons, LLB; EDWARD (TED) LAIN, MD, MBA; GLYNIS ABLON, MD; VIVIAN BUCAY, MD; CHERYL BURGESS, MD;
JAMES DEL ROSSO, DO; PATRICIA K. FARRIS, MD; JILL WAIBEL, MD; DENISE DICANIO, EdD, MBA; and SARAH VICKERY
In the cosmeceuticals and aesthetics field, there has been a paradigm shift from addressing existing symptoms of skin aging to modulating the cellular processes that underlie the aging process, representing a focal shift from anti-aging to pro-longevity. This focal shift suggests that cosmeceuticals that prevent aging will form the foundation of the next generation of skincare products.1
One of the hallmarks of aging is cellular senescence, a state of irreversible cell cycle arrest in which cells no longer proliferate but remain metabolically active.2,3 Accumulation of senescent cells within the skin, a result of intrinsic (chronological) and extrinsic aging, is associated with epidermal thinning, flattening of the dermal-epidermal junction, hyperpigmentation, loss of melanocytes, and degradation of collagen and elastin.45 These physiological changes, in turn, are reflected in the visible signs of skin aging, such as laxity, wrinkles, and volume loss.
