FOCUS #9: Antera 3D & anti-ageing claims by Miravex

5 December 2023

Skin aging depends on a variety of factors: your lifestyle, diet, heredity, and other personal habits. Notable risk factors include age, gender, ethnicity, air pollution, nutrition, smoking, sun exposure. Anti-Aging involves a wide range of claims that are designed to make consumers look and feel younger and more vibrant. To support anti-aging claims, a product should result in the improvement of several aspects of the skin including wrinkles, skin toning and eveness, age spot and hyperpigmentation reduction, skin firmness, pore size reduction, moisturazion, skin smoothness, etc.

Thanks to its versatility, the Antera 3D can be used to support many of the claims related to anti-aging.

Here, we cite a few publications^[1]^,^[2]^,^[3]^,^[4]^,^[5] that have used the Antera 3D for anti-ageing claims, and we will focus on a very recent publication[6] using the Antera 3D to measure a lifting effect in the eye area, the reduction of wrinkles and the evaluation of facial pillow marks relief effect. In this study, caviar oil was investigated as an ingredient to combat the signs of aging – to potentially reduce wrinkles and skin sagging – thanks to its rich composition of fatty acids, vitamins, and minerals. The in-vitro and ex-vivo analysis was supported by a clinical study, demonstrating that caviar oil has a substantial impact on mitigating skin aging and holds potential for application in anti-aging products.

The Antera 3D was used to investigate six types of deep wrinkles – forehead, glabellar, nasolabial folds, marionette, lips, and neck wrinkles. In all cases a significant reduction in the wrinkles’ depth was measured after one-time use and four weeks of use.

The volume measurements of the Antera 3D were used to evaluate the decrease of induced pillow marks, as shown in Figure 1.

Figure 1. ANTERA 3D images of induced pillow marks and measurements of their volume.

The Antera 3D was also used to evaluate three types of eye area lifting (skin filling), including the eyelid area, the area under eye bags, and the outer corner of the eye, as well as the analysis of marionette lines lifting. The results showed significant improvement compared to before using the product, as shown in Figure 2 in the case of marionette lines.

Figure 2. ANTERA 3D images of marionette line lifting and decrease of volume. Data are shown as the mean ± SEM. *p<0.05. BU: Before use; AU: after use.

Furthermore, the evaluation of the effectiveness in minimizing makeup entrapment, which can result in clogged pores and acne, was conducted. The Antera 3D analysis results showed that compared to before and after applying foundation, the skin volume parameter value significantly increased in the control group while notably decreasing in the group treated with caviar oil.

Figure 3. Evaluation of the effect of Cavi Balm on reducing makeup entrapment compared to the Control group as measured with the ANTERA 3D.

[1] Majeed M. et al., “An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects”, Clinical, Cosmetic and Investigational Dermatology, 105-116, DOI: 10.2147/CCID.S238358.

[2] Trivisonno A. et al., “Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: clinical evaluation and skin surface digital profilometry analysis”, British Journal of Plastic Surgery (2017), doi: 10.1016/j.bjps.2017.04.002.

[3] Yogya Y. et al., “Efficacy and Safety of Using Non-insulated Microneedle Radiofrequency Alone

versus in Combination with Polynucleotides for Treatment of Periorbital Wrinkles”, Dermatol Ther (Heidelb) (2022) 12:1133–1145.

[4] Sekyoo J. et al., “Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression”, Int. J. Mol. Sci. 2020, 21, 73; doi:10.3390/ijms21010073.

[5] Adatto M. et al., “Facial treatment with acoustic wave therapy for improvement of facial skin texture, pores and wrinkles”, J Cosmet Dermatol. 2020;00:1–5.

[6] Le L. et al., “Investigating the Anti-Aging Effects of Caviar Oil on Human Skin”, in vivo 37: 2078-2091 (2023).

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