Polyphenols from Upcycled Cork for Skin Protection and Well-Ageing Activity via HPC Today

Cork residues represent a sustainable source of bioactive cosmetic ingredients. The aim of this study was to evaluate the in vivo efficacy of a polyphenol-rich extract obtained from Quercus suber L. on skin hydration and wrinkle appearance. The positive effects previously observed in an in vitro study were confirmed by an in vivo clinical evaluation. A randomized, double-blind, hemi-face clinical study was conducted over 8 weeks. Topical application increased skin hydration by up to 14.8% versus baseline, while periocular wrinkle number and perimeter were reduced by 9.4% and 9.2%, respectively, compared with placebo. These effects are consistent with the extract’s ability to support extracellular matrix. The results validate this cork-derived extract as an effective and sustainable well-ageing cosmetic active.