By Xingzuo Liu, Juanjuan Chen, Chengda Ye, Andrew Steel, Yidong Tu, Frederic Flament, Jing Li
Abstract :
Objective: This study aimed to develop and validate a novel, integrated dynamic wrinkle assessment system based on standardized, real-time and multi-angle facial images and video recordings, and to explore its potential application in evaluating the anti-wrinkle efficacy of skincare products.
Methods: A standardized protocol was developed for a novel system integrating a high-precision positioning apparatus with synchronized, multi-angle high-speed cameras to capture facial expressions from a neutral to a maximal state. To ensure longitudinal consistency, a novel algorithm was used to select analysis frames based on angular congruence. The system’s reproducibility and accuracy were validated by expert dermatologists using the intraclass correlation coefficient (ICC). The system’s feasibility and effectiveness were assessed in an 8-week anti-wrinkle cream efficacy trial.
Results: The integrated dynamic wrinkle evaluation system demonstrated high inter-rater reliability (ICC >0.70) across 35 Chinese women, with ICC values exceeding 0.900 for key facial areas. In an anti-aging efficacy trial (n = 42), the system successfully detected and quantified significant improvements (p < 0.05) in both static and dynamic wrinkles following product use.
Conclusion: This study successfully developed and validated an all-in-one dynamic wrinkle photo grading evaluation system for personalized assessment of treatment outcomes following topical application of cosmetic products. The high accuracy of the clinician evaluations offers a new approach for assessing the effects of anti-aging skincare and cosmetic products, surpassing traditional static assessment methods.
Keywords: computer modelling; dermatology; dynamic wrinkles; formulation; static wrinkles; statistics.
